Methyl Folate supplies 1,000 mcg of biologically active folate per tablet from Metafolin®, a patented, natural form of (6S) 5-methyltetrahydrofolate (5-MTHF). 5-MTHF is the naturally occurring, predominant form of folate commonly found in cells and is essential for overall health. Unlike synthetic folic acid, 5-MTHF can be used directly by the body, without the need for an additional conversion via the enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR). In certain populations, the body’s ability to convert folic acid to 5-MTHF by use of this enzyme may be compromised due to genetic differences.
Metafolin® contains only the S isomer of 5-MTHF and has been shown to be the only form of folate to be able to cross the blood-brain barrier. Folate is a water-soluble essential B vitamin found in many foods, including leafy green vegetables, citrus fruits and beans. Research has established that supplementation with folate before and during the first two months of pregnancy can prevent neural tube defects in the fetus. Additionally, folate plays a key role in red blood cell production and the formation of methionine.
All Douglas Laboratories products are GMO-free. All allergens are disclosed on the label in accordance with Health Canada labeling guidelines for the 11 major allergens: eggs, milk, mustard, peanuts, seafood, sesame, soy, sulphites, tree nuts, wheat and gluten. Comprehensive allergen procedures are in place to prevent ingredient cross-contamination during manufacturing and storage.